Effect of Corticosteroid Treatment on Prognosis in ARDS Secondary to Covid-19 (CoCovSDRA)

Central Hospital, Nancy, France

Status: Unknown

Conditions: Acute Respiratory Distress Syndrome Secondary to Covid-19

Treatments: Drug: Corticosteroids and Derivatives

Study type: Observational

Funder types: Other

Identifiers

NCT04586114

2020PI109

Details and patient eligibility

About

Study conducted on hospitalized patient in critical ill units in Nancy and Metz to evaluate if early corticosteroid treatment in first seven days after admission improve patients outcome in Acute Respiratory Distress Syndrome secondary to Covid-19 compared to later corticosteroid therapy or no treatment. Also comparison of acquired infection with or without corticosteroid treatment during hospitalisation.

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ICU hospitalized with acute respiratory distress syndrome secondary to Sars-Cov-2 infection diagnosed by PCR test
• Hospitalized from 01/03/2020 to 30/04/2020

Exclusion criteria

• Mechanical ventilation more than 48 hours at admission
• Transfert to another ICU during stay for bed management
• Corticosteroid treatment at admission

Trial design

200 participants in 3 patient groups

Early corticosteroid

Description:

Corticosteroid treatment within first seven days after ICU admission

Treatment:

Drug: Corticosteroids and Derivatives

Late corticosteroid

Description:

Corticosteroid treatment later than seventh day's after ICU admission

Treatment:

Drug: Corticosteroids and Derivatives

No corticosteroid

Description:

No corticosteroid treatment during ICU stay