Effect of COVID-19 Infection on Obstertric Complications and Maternal Outcomes

Tanta University

Status: Completed

Conditions: COVID-19; Infection; Maternal Outcomes; Obstetric Complication

Treatments: Other: Data collection

Study type: Observational

Funder types: Other

Identifiers

NCT06557694

36264PR750/7/24

Details and patient eligibility

About

This study aimed to evaluate the effect of COVID-19 infection on obstetric complications and maternal outcomes.

Full description

During the SARS-CoV-2 pandemic, pregnant women were reported to have a higher susceptibility to COVID-19 infection. Pregnant women who tested positive for SARS-CoV-2 are at higher risk of a severe form of COVID-19, associated with higher rates of intensive care unit (ICU) admission and increased needs for respiratory support, compared to the age-matched non-pregnant population.

Women infected during pregnancy also have an increased risk of adverse pregnancy outcomes including preterm-birth, with a significant proportion secondary to iatrogenic preterm birth due to maternal illness. Infection with SARS-CoV-2 during pregnancy has also been reported to be associated with a higher risk of stillbirth directly or indirectly caused by the virus.

Infected pregnant patients tended to present asymptomatically with pre-Delta and Omicron variants, and symptomatically with Delta variant. A previous systematic review suggested that people who are pregnant did not have an increased risk of SARS-CoV-2 infection or symptomatic COVID-19, but they were at risk of severe COVID-19 compared with those who were not pregnant.

Enrollment: 260 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 40 years.
• Pregnant women with COVID-19 infection diagnosed either by PCR or rapid test.

Exclusion criteria

• Patients vaccinated for COVID-19 before or during the current pregnancy.

Trial design

260 participants in 1 patient group

Data collection

Description:

Data collected included maternal demographics, medication during pregnancy, the gestational week when COVID-19 was diagnosed, antenatal diseases occurring after COVID-19 detection during pregnancy, intrauterine growth retardation (IUGR), small for gestational age (SGA), fetal distress, intrauterine fetal demise (IUFD), intrapartum complications, gestational age (GA) at delivery, mode of delivery, postpartum hemorrhage (PPH), admission to the maternal ICU, birth weight, admission to the NICU, and the indication for NICU hospitalization

Treatment:

Other: Data collection