Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea

National Jewish Health

Status

Completed

Conditions

Asthma

Sleep Apnea

Treatments

Device: CPAP machine as a result of sleep study

Study type

Interventional

Funder types

Other

Identifiers

NCT00238069

HS-1866

Details and patient eligibility

About

This is a research study of asthma and sleep apnea. Our hypothesis is that untreated sleep apnea causes inflammation in the lung, which can worsen asthma. We believe treatment of sleep apnea will reduce this inflammation, and improve asthma control. This study will help us better understand what happens to the lung and bronchial tubes before and after treatment of sleep apnea, which could benefit all patients with sleep apnea. This study involves 2 bronchoscopies.

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult (>18yrs at the time of recruitment)
Body mass index (BMI) ≥ 30
Symptoms suggestive of sleep apnea
Epworth Sleepiness Score (ESS) within range
Positive sleep study for sleep apnea

Exclusion criteria

Tobacco use within the last 3 months.
Presence of other significant comorbid heart or lung disease
Presence of another chronic inflammatory disease, such as connective-tissue disease, inflammatory bowel disease, or active infection.
Use of systemic steroids, as defined as any prednisone use in the preceding 3 months.
Use of leukotriene antagonists or theophylline within the preceding 6 weeks.
Presence of severe or uncontrolled sinusitis, such that CPAP therapy will be difficult or uncomfortable.
History of significant claustrophobia, uncontrolled psychiatric disease, or anticipated intolerance of CPAP therapy.
Night shift workers, or other subjects with significantly altered sleep-wake cycles.
Baseline post-bronchodilator FEV1 < 70% predicted.
Severe gastroesophageal reflux disease.