Effect of CPAP on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension

Corporacion Parc Tauli

Status: Completed

Conditions: Refractory Arterial Hypertension; Obstructive Sleep Apnea

Treatments: Device: CPAP; Device: Control

Study type: Interventional

Funder types: Other

Identifiers

NCT00863135

FIS PI070219

Details and patient eligibility

About

The purpose of this study is to determine the effects of CPAP treatment on blood pressure in patients with sleep apnea syndrome (SAS) and refractory arterial hypertension (RAH).

Also, some of the mechanisms mediating SAS and RAH (systemic inflammation, oxidative stress, sympathetic hyperactivity) will be analyzed.

Enrollment: 68 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• refractory arterial hypertension and sleep apnea with apnea-hypopnea index over 15

Exclusion criteria

• excessive sleepiness
• professional drivers
• secondary arterial hypertension

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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68 participants in 2 patient groups

Continuous Positive Airway Pressure

Experimental group

Description:

nocturnal continuous positive airways pressure

Treatment:

Device: CPAP

Control

Other group

Description:

Waiting list,3 months without any change in their treatment, come into the CPAP procedure after that time

Treatment:

Device: Control