Effect of Cranberry Juice on Endothelial Function

Boston University

Status

Completed

Conditions

Coronary Artery Disease

Treatments

Dietary Supplement: Cranberry juice

Study type

Interventional

Funder types

Other

Identifiers

NCT00553904

H-26708

Details and patient eligibility

About

A pilot study of 15 subjects will be completed to determine whether acute consumption of cranberry juice has an effect on endothelial function. We will then complete a randomized, double blind, placebo controlled crossover study designed to investigate the effects of cranberry juice consumption on endothelial function. Participants (n=40) will drink 480 ml of double strength cranberry juice or a similar appearing and tasting placebo per day for four weeks. After a two week rest period, they will cross over to the other beverage. We will examine endothelial function before and after each of the two treatment periods. The study will provide information about the chronic vascular effects of cranberry juice.

Enrollment

40 estimated patients

Sex

All

Ages

21 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Coronary artery disease

Exclusion criteria

Pregnant and lactating women
Clinical history of other major illness including end-stage cancer, renal failure, hepatic failure, gastrointestinal disorders that may impair absorption, or other conditions that in the opinion of the principal investigator make a clinical study inappropriate
Treatment with an investigational new drug within the last 30 days
History of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study.
Treatment with Vitamin E, Vitamin C, beta carotene, lipoic acid, or other food or herbal supplements within 2 weeks of enrollment (subjects taking multivitamins or other forms of vitamin E and C in doses that do not exceed two times the RDA will not be excluded).