Effect of Creatine and L-Arginine on Endothelial Function

Boston University

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Dietary Supplement: L-arginine and creatine; Dietary Supplement: l-arginine; Dietary Supplement: Creatine; Dietary Supplement: placebo, double

Study type: Interventional

Funder types: Other

Identifiers

NCT00551434

H-22852

Details and patient eligibility

About

The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement. The function of the endothelium will be tested using ultrasound before and after each treatment. These studies will help us understand why the endothelium is abnormal in patients with coronary artery disease and how L-arginine is acting on endothelial function.

Enrollment: 119 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Coronary artery disease

Exclusion criteria

• Pregnancy
• Creatine use within one month of study
• L-arginine use within one month of study
• Change in dose or initiation of lipid lowering therapy, aspirin therapy, or angiotensin converting enzyme therapy within one month of study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Triple Blind

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119 participants in 4 patient groups, including a placebo group

1

Experimental group

Treatment:

Dietary Supplement: Creatine

2

Experimental group

Treatment:

Dietary Supplement: l-arginine

3

Experimental group

Treatment:

Dietary Supplement: L-arginine and creatine

4

Placebo Comparator group

Treatment:

Dietary Supplement: placebo, double