Effect of Cyanoacrylate and Concentrated Growth Factor on Palatal Donor Site

Yuzuncu Yil University

Status: Completed

Conditions: Patient Comfort; Wound Healing; Pain

Treatments: Procedure: Free gingival graft procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT06459947

28.02.2024/07

Details and patient eligibility

About

The aim of this planned randomized controlled clinical study is to evaluate the morbidity of the palatal donor area after free gingival graft (FGG) operations. In this study, wound healing and pain levels in the palatal region will be evaluated after cyanoacrylate and concentrated growth factor (CGF) applications.

Full description

Free gingival graft obtained in the palatal region causes morbidity. Therefore, clinicians try to overcome these difficulties by isolating the wound in the palatal region from the oral environment and/or accelerating wound healing.

Periodontal dressings, acrylic stents, hemostatic agents, surgical sponges, platelet concentrates, low-level laser therapy, photobiomodulation, cyanoacrylate tissue adhesives and hyaluronic acid are some of the methods used for donor site management or to accelerate healing.

Cyanoacrylate adhesives form an adhesive film through rapid polymerization triggered by the hydroxyl groups on the surfaces to which they are applied. They have both bacteriostatic and hemostatic properties.

In recent years, it has been observed that the use of platelet concentrates such as Platelet Rich Plasma (PRP), Platelet Rich Fibrin (PRF) and autogenous products such as CGF (concentrated growth factor) in periodontal treatments has increased.

CGF is obtained by centrifuging blood in four different cycles and times. This product contains a relatively intact fibrin clot containing platelets, leukocytes, various growth factors and cytokines. CGF can be applied as a carrier of growth factors and/or a barrier membrane to aid tissue regeneration and wound healing in clinical applications.

The aim of this planned randomized controlled clinical study is to evaluate the morbidity of the palatal donor area after FGG operations. In this study, wound healing and pain levels in the palatal region will be evaluated after cyanoacrylate and CGF applications.

Enrollment: 60 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• systemically healthy
• not had periodontal surgery in the last 6 months

Exclusion criteria

• smoker
• allergic to medication
• high anxiety (using modified dental anxiety scale)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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60 participants in 3 patient groups

Group 1 (Control group)

Active Comparator group

Description:

After FGG is taken from the palatal area, the sponge is placed in the wound area.

Treatment:

Procedure: Free gingival graft procedure

Group 2 (Cyanoacrylate group)

Active Comparator group

Description:

After the FGG is taken from the palatal area, a cyanoacrylate tissue adhesive is placed in the wound area.

Treatment:

Procedure: Free gingival graft procedure

Group 3 (Concentrated Growth Factor group)

Active Comparator group

Description:

After the FGG is taken from the palatal area, concentrated growth factor (CGF) group is placed in the wound area. CGF is obtained by centrifuging blood in four different cycles and times.

Treatment:

Procedure: Free gingival graft procedure