Effect of CYP2C9*3 Polymorphism on Ibuprofen in Pakistani Population

Riphah International University

Status: Completed

Conditions: Healthy Volunteers

Treatments: Genetic: Ibuprofen

Study type: Observational

Funder types: Other

Identifiers

NCT05983042

Riphah/IIMC/IRC/22/2072

Details and patient eligibility

About

The goal of this Observational study was to identify the effect of CYP2C9 gene polymorphism in the Pakistani population. The main question it aims to answer were:

• to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen
• to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction.

Full description

The goal of this observational study was to identify the effect of CYP2C9*3 gene polymorphism in the Pakistani population, due to the high prevalence of this variant in the Pakistani Population

The main question it aims to answer were:

• to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen
• to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction.

The blood samples of the participants were taken and further genotyping was performed using conventional tetraARMS PCR. The results were visualized by gel electrophoresis.

Enrollment: 200 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pakistani individuals
• Absence of systemic diseases
• Extractions required based on orthodontic, periodontal, and endodontic indications

Exclusion criteria

• history of bleeding or gastrointestinal ulcers
• allergic to ibuprofen or other NSAIDs.
• Pregnancy