Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects

Mass General Brigham

Status: Completed

Conditions: Healthy

Treatments: Drug: aspirin

Study type: Interventional

Funder types: Other

Identifiers

NCT00898222

ARC ASA Normal

Details and patient eligibility

About

Hypothesis: Low dose aspirin does not change exhaled inflammatory breath mediators in normal subjects.

Full description

Aim:

1. To study the effect of low dose aspirin on exhaled breath inflammatory mediators
2. To compare the change to that seen in diseased states such as asthma and Lymphangioleiomyomatosis (LAM)

We will interview healthy volunteers to confirm that they do not have any major underlying medical conditions such as heart disease, diabetes, stroke and bleeding disorders. We will collect breath condensate before and after two weeks of low dose over the counter enteric coated aspirin 81 mg/day therapy. Side effects are extremely rare at this dose, but include bleeding, heart burn and allergic reaction.

Enrollment: 4 patients

Sex: All

Ages: 18 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adults

Exclusion criteria

• any underlying major medical conditions such as heart disease, hypertension, stroke, diabetes, bleeding disorders

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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4 participants in 1 patient group

aspirin

Experimental group

Description:

Low dose daily aspirin in healthy volunteers for two weeks

Treatment:

Drug: aspirin