Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids

Chongqing Medical University

Status: Completed

Conditions: Postoperative Hyperalgesia

Treatments: Drug: Remifentanil

Study type: Observational

Funder types: Other

Identifiers

NCT05234697

Postoperative hyperalgesia

Details and patient eligibility

About

To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were respectively included. Postoperative hyperalgesia at PACU and 24 hours after surgery were assessed through mechanical pain measurement. Comparative analysis of postoperative hyperalgesia levels, pain and analgesic requirements between morning group and afternoon group were performed.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists classification I-II
• Abdominal endoscopy surgery
• Estimated surgery duration 1-2h
• Right handedness
• Voluntarily receive postoperative intravenous controlled analgesia

Exclusion criteria

• Heavy smoking or alcohol dependence
• Puerpera or lactation women
• History of chronic pain
• Analgesic use within one month before surgery
• Allergy to opioids
• Can not follow with the study procedure

Trial design

60 participants in 2 patient groups

Morning group

Description:

Surgery performed during 08:00 to 12:00

Treatment:

Drug: Remifentanil

Afternoon group

Description:

Surgery performed during 14:00 to 18:00

Treatment:

Drug: Remifentanil