Effect of Deep Brain Stimulation on Neuropsychiatric Fluctuations in Patients With Parkinson's Disease (PSYCHOSTIM)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Parkinson's Disease (Disorder)

Treatments: Other: none (observational study)

Study type: Observational

Funder types: Other

Identifiers

NCT04608123

0

Details and patient eligibility

About

Retrospective, monocentric, observational study designed to evaluate the effects of Bilateral Subthalamic Nucleus Deep Brain Stimulation (DBS STN) on Neuropsychiatric fluctuations in Patients with Parkinson's Disease (PD)

Full description

Pre-operative versus 12-Month Follow-Up analysis of changing in Neuropsychiatric Fluctuations Scale (NFS) score in preoperative versus postoperative MED OFF (during acute withdrawal of dopaminergic therapy) and MED ON (during super-liminal Levodopa dose) conditions. Postoperative evaluations are always performed with DBS turned on and stimulating (STIM ON)

Enrollment: 31 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's disease
• Treatment with Bilateral STN DBS
• Evaluation with NFS in both preoperative and 12 months post-surgery follow-up context

Exclusion criteria

• DBS for non PD patients
• Unilateral DBS or other DBS targets
• Patients not evaluated with NFS
• Patients with incomplete preoperative evaluation
• Patients who refused the use of their data

Trial design

31 participants in 1 patient group

DBS Patients with NFS

Description:

Patients with PD treated with STN DBS between 2016 and 2019 who underwent NFS testing in pre and post-op conditions

Treatment:

Other: none (observational study)