Effect of Deksmedetomidine and Remifentanil in Extubation Agitation (EA)

Diskapi Yildirim Beyazit Training and Research Hospital

Status and phase: Unknown; Phase 4

Conditions: Agitation

Treatments: Drug: Saline; Drug: deksmedetomidine; Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT02104297

Agitation

Details and patient eligibility

About

To compare the effect of two different agents deksmedetomidine, remifentanil and placebo, agitation and recovery condition, on nasal septum operation.

Full description

Nasal septum operation cause agitation because of nasal package. This research aims determine which agent , deksmedetomidine remifentanil or placebo, is more beneficial to the patient.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult patients

Exclusion criteria

• patients with any sensitivity each drug

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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90 participants in 3 patient groups, including a placebo group

Deksmedetomidine infusion

Active Comparator group

Description:

To prevent agitation deksmedetomidine infused during operation and at the end of surgery agitation scor measured by Riker sedation agitation scale.

Treatment:

Drug: deksmedetomidine

Remifentanil infusion

Experimental group

Description:

To prevent agitation remifentanil infused during operation at the end of surgery agitation scor measured by Riker sedation agitation scale.

Treatment:

Drug: Remifentanil

Saline infusion

Placebo Comparator group

Description:

Saline infused during operation and at the end of surgery agitation scor measured by Riker sedation agitation scale.

Treatment:

Drug: Saline