Effect of Desflurane Versus Sevoflurane With Recent Bio-markers on Renal and Hepatic Functions

T

Theodor Bilharz Research Institute

Status

Completed

Conditions

Postoperative Complications

Treatments

Drug: Sevoflurane
Drug: Desflurane
Diagnostic Test: Neutrophil Gelatinase-Associated Lipocalin (NGAL)

Study type

Observational

Funder types

Other

Identifiers

NCT05027191
110-T

Details and patient eligibility

About

Studying the effects of both inhalational anesthetics desflurane and sevoflurane on hepatic integrity and renal function, guided by recent blood and urine biomarkers in patients undergoing laparoscopic cholecystectomy surgery.

Enrollment

70 patients

Sex

All

Ages

25 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • American Society of Anesthesiologists (ASA) Class: I&II.
  • Elective laparoscopic cholecystectomy.
  • Age: 25-55 years.
  • Gender: Both male and female.
  • Body Mass Index (BMI): 18.5-24.9 km2-(Normal weight).

Exclusion criteria

  • Extremes of age.
  • Abnormal hepatic function by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values outside the normal range.
  • Abnormal renal function by blood urea nitrogen (BUN) and creatinine above the normal ranges.
  • Hypertension, unstable angina pectoris or myocardial infarction within the last six months.
  • Pregnancy and lactation.
  • Bronchial asthma.
  • Drug allergies.
  • Alcohol or drug addiction.
  • General anesthesia within the last three months.

Trial design

70 participants in 2 patient groups

Sevoflurane
Description:
This group will receive sevoflurane as the maintenance inhalational anesthetic.
Treatment:
Diagnostic Test: Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Drug: Sevoflurane
Desflurane
Description:
This group will receive desflurane as the maintenance inhalational anesthetic.
Treatment:
Diagnostic Test: Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Drug: Desflurane

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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