Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine

Yeungnam University College of Medicine

Status: Unknown

Conditions: Postoperative Pain

Treatments: Drug: Dexamethasone; Drug: Epinephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT02104778

apsj20140401

Details and patient eligibility

About

The aim of the present study is to test that adding dexamethasone or epinephrine significantly prolongs the duration of sciatic nerve blocks with ropivacaine and that the magnitude of the effect differs among dexamethasone and epinehrine.

Full description

In a double-blinded trial utilizing single-injection sciatic nerve block, patients are randomly assigned to one of three groups: control: 0.5% ropivacaine adding normal saline; epinephrine: 0.5% ropivacaine adding epinephrine; dexamethasone: 0.5% ropivacaine adding dexamethasone. We assess time to first analgesic request after post-anaesthesia care unit discharge.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status I and II
• patients undergoing elective hallux valgus repair

Exclusion criteria

• patients receiving chronic analgesic therapy
• diabetes
• peripheral neuropathies
• psychiatric disorders
• hypersensitivity to amide local anesthetics
• renal disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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90 participants in 3 patient groups, including a placebo group

Dexamethasone

Experimental group

Description:

Dexamethasone 8 mg is added to 0.5% ropivacaine 20 ml for sciatic nerve block.

Treatment:

Drug: Dexamethasone

Control

Placebo Comparator group

Description:

Normal saline 1 ml is added to 0.5% ropivacaine 20 ml for sciatic nerve block.

epinephrine

Experimental group

Description:

Epinephrine 1:200,000 is added to 0.5% ropivacaine 20 ml for sciatic nerve block.

Treatment:

Drug: Epinephrine