Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty

Naestved Hospital

Status and phase: Completed; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: Dexamethasone; Drug: Isotonic saline

Study type: Interventional

Funder types: Other

Identifiers

NCT05008367

SM1-KAKG-2021

Details and patient eligibility

About

Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty: Subgroup Analyses of The DEX-2-TKA Randomized Clinical Trial This explorative post-hoc analysis is a substudy of the DEX-2-TKA-trial (NCT03506789) investigating diffefferent subgroups of the patients included in the main trial.

Full description

Effect of Dexamethasone as Analgesic Treatment After Total Knee Arthroplasty: Subgroup Analyses of The DEX-2-TKA Randomized Clinical Trial This explorative post-hoc analysis is a substudy of the DEX-2-TKA-trial (NCT03506789) investigating diffefferent subgroups of the patients included in the main trial.

Enrollment: 485 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Participation in the DEX-2-TKA-trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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485 participants in 3 patient groups, including a placebo group

Treatment A

Active Comparator group

Description:

24 mg dexamethasone i.v. perioperatively and 24 mg dexamethasone i.v. on the first postoperative day

Treatment:

Drug: Dexamethasone

Treatment B

Active Comparator group

Description:

24 mg dexamethasone i.v. perioperatively and placebo (isotonic saline) i.v. on the first postoperative day

Treatment:

Drug: Isotonic saline

Drug: Dexamethasone

Placebo

Placebo Comparator group

Description:

Placebo (isotonic saline) i.v. perioperatively and placebo (isotonic saline) i.v. on the first postoperative day

Treatment:

Drug: Isotonic saline