Effect of Dexamethasone Combined With Ondansetron on Postoperative Nausea and Vomiting in Patients With Patient-controlled Analgesia After Video-assisted Thoracoscopic Surgery

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Vomiting; Nausea

Treatments: Drug: Ondansetron; Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT01007500

4-2009-0407

Details and patient eligibility

About

The purpose of this study is to study the effect of dexamethasone combined with ondansetron on postoperative nausea and vomiting in patients with patient-controlled analgesia after video-assisted thoracoscopic surgery.

Enrollment: 123 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing video-assisted thoracoscopic surgery
• Age 20-75
• American Society of Anesthesiologists physical status classification I or II

Exclusion criteria

• Antiemetic within 24 hrs
• Taking Steroids, Opioids within 1 week
• Active drug or alcohol abuse
• GI motility disorder, severe renal/ hepatic disease.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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123 participants in 2 patient groups

Group Dexamethasone

Experimental group

Treatment:

Drug: Dexamethasone

Group Ondansetron

Active Comparator group

Treatment:

Drug: Ondansetron