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This study evaluates the effect of dexamethasone implant which is an intraocular corticosteroid on the optic nerve fibers. Retinal nerve fiber thicknesses and optic nerve head pitting rates were measured before and 6 months after the injection.
Full description
Diabetic macular edema is the most frequent ocular complication of diabetes resulting in irreversible loss of vision if untreated. Dexamethasone implant implant is used to treat macular edema due to diabetes. It stay in the vitreous for 6 months after intravitreal administration.
Dexamethasone implant can lead to retinal nerve fiber layer and optic nerve damage by both increasing intraocular pressure and its direct effect on neural tissue during the effective 6-month period.
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Inclusion and exclusion criteria
Inclusion Criteria
Patients who underwent first time intravitreal injection
Exclusion Criteria
Previously received any surgery
Proliferative diabetic retinopathy
Glaucoma or glaucoma suspicion
Optic disc fatigue
Optic disc edema
Uveitis and media opacity
Blurred of image clarity
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Data sourced from clinicaltrials.gov
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