Effect of Dexamethasone on Postoperative Inflammatory Factors

General Hospital of Ningxia Medical University

Status: Completed

Conditions: Inflammation

Treatments: Drug: Dexamethasone Injection; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT04981093

2020-519

Details and patient eligibility

About

This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the inflammation, the observation of elderly patients with lumbar spinal postoperative drainage star, to explor whether low-dose dexamthasone can reduce postoperative incision drainage, thus impove the postoprative drainage tube pull rate within three days, which in turn reduce because of the place a retrograde infection caused by drainage tube.

Full description

A total of 100 patients undergoing posterior lumbar disc fusion were randomly divided into control group (group C,n=50) and dexamethasone group (group D,n=50). Group D was given 0.15mg/kg dexamethasone (2ml) intravenously after anesthesia induction. Group C was also intravenously injected with 2ml normal saline after anesthesia induction.On this basis, monitor the main results and secondary results

Enrollment: 120 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Adult patients ≥65years of age
• American Society of Anesthesiologists (ASA) physical status 2-4
• Elective or expedited non-cardiac surgery of at least 2 hours dura- tion under general anaesthesia
• Requiring a hospital stay of at least one postoperative night
• A surgical skin incision >5 cm in length or multiple incisions with a total incision length of >5 cm

Exclusion Criteria:·

• Poorly controlled diabetes (HbA1c>9.0%)
• Endovascular procedure with a small (<5 cm length) skin incision Ophthalmic surgery
• Planned dexamethasone (or other corticosteroid) therapy (eg, history of intractable PONV, maxillofacial surgery, intracranial neurosurgery)
• Recent (<2 weeks since end of treatment) infective episode requir- ing treatment with antibiotics
• Chronic antibiotic therapy (eg, for bronchiectasis, cystic fibrosis etc)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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120 participants in 2 patient groups, including a placebo group

Group Dexamethasone

Experimental group

Description:

Group dexamethasone patients received intravenous injection after anesthesia induction Injection 0.15mg/kg dexamethasone (2ml）

Treatment:

Drug: Dexamethasone Injection

Group Saline

Placebo Comparator group

Description:

Group Control patients were also given 2ml of normal saline intravenously after induction of anesthesia

Treatment:

Drug: Normal saline