Effect of Dexmedetomidine and Propofol on Regional Cerebral Tissue Oxygen Saturation

Ain Shams University

Status: Completed

Conditions: Regional Cerebral Tissue Oxygen Saturation

Treatments: Drug: Propofol 10 MG/ML; Drug: Dexmedetomidine Hydrochloride 0.1 MG/ML

Study type: Interventional

Funder types: Other

Identifiers

NCT03817112

ASCSH86/17

Details and patient eligibility

About

50 patients divided into 2 groups

.Group I Dexmedetomidine infusion. Group II with Propofol infusion

Full description

: 50 patients anticipated for open heart surgeries were encompassed in the study. Patients were divided into 2 groups, group P (receiving propofol) and group D (receiving dexmedetomidine) during CPB. Both groups were studied for variations in right and left rScO2 as well as postoperative cognitive dysfunction using the Mini Mental State Examination Score (MMSE) test.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing valve surgeries
• Patients undergoing on pump coronary artery bypass grafting surgeries

Exclusion criteria

• emergency cases, patients with cervical spine pathology (cervical stenosis, cervical disc herniation, carotid stenosis), patients with cerebral pathology (cerebral strokes, ischemic attacks), patients with Mini Mental State Examination Score (MMSE) of 23 or less, complicated cases with prolongation of the cardiopulmonary bypass period, patients needing moderate hypothermia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Dexmedetomidine

Active Comparator group

Description:

Infusion of dexmedetomidine

Treatment:

Drug: Dexmedetomidine Hydrochloride 0.1 MG/ML

Propofol

Active Comparator group

Description:

Propofol infusion

Treatment:

Drug: Propofol 10 MG/ML