Effect of Dexmedetomidine As Adjuvant to Ropivacaine for Brachial Plexus Block

Nepal Medical College and Teaching Hospital

Status: Completed

Conditions: Brachial Plexus Block; Upper Extremity Fracture; Local Anesthesia Adjuvants

Treatments: Drug: Dexmedetomidine, ropivacaine, lidocaine with adrenaline; Drug: ropivacaine, lidocaine with adrenaline

Study type: Interventional

Funder types: Other

Identifiers

NCT05767827

NepalMCTH

Details and patient eligibility

About

Brachial plexus block is used for upper limb surgery. Local anesthesia alone for brachial plexus block provides good operative conditions, but have short duration of postoperative analgesia. Hence, various adjuvants to local anaesthetic agents to prolong the duration of peripheral nerve, analgesia. However, results are either inconclusive or associated with side effects. The purpose of this study is to determine whether dexmedetomidine as an adjuvant to ropivacaine in brachial plexus block improve quality of block in terms of duration of post operative analgesia.

Enrollment: 40 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I and II patients, weight 45 to 74 kg
• Elective upper limb surgery under brachial plexus block

Exclusion criteria

• known hypersensitivity or contraindication to ropivacaine, lidocaine and dexmedetomidine
• Pregnant or lactating mothers
• Hepatic, renal or cardiopulmonary abnormalities
• Long term analgesic therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Group R

Active Comparator group

Description:

0.35% ropivacaine 20ml, 1.5% lidocaine with adrenaline 10ml = 30 ml

Treatment:

Drug: ropivacaine, lidocaine with adrenaline

Group RD

Experimental group

Description:

0.35% ropivacaine and 1mcg/ kg dexmedetomidine (20 ml), 1.5% lidocaine with adrenaline (10ml) = 30 ml

Treatment:

Drug: Dexmedetomidine, ropivacaine, lidocaine with adrenaline