Effect of Dexmedetomidine Infusion on Post Anesthesia Discharge Time

Shaukat Khanum Memorial Cancer Hospital & Research Centre

Status: Completed

Conditions: Post Anesthesia Discharge Time in Patients of Breast Cancer Surgery

Treatments: Drug: Dexmedetomidine infusion low dose; Drug: Group B receiving normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT07180810

IRB-23-14

Details and patient eligibility

About

A randomised control trial evaluating the effect of low dose dexmedetomidine infusion on post anesthesia discharge time in patients of day case breast cancer surgery compared with placebo infusion. The primary outcome was to compare the frequency of early discharge in each group.

Full description

A prospective Randomised control trial evaluating the effect of low dose dexmedetomidine infusion on post anesthesia discharge time in patients of day case breast cancer surgery compared with placebo infusion. The primary outcome was to compare the frequency of early discharge in each group. Early discharge was defined as within two hours. The sample size was of 82 female patients with a specific inclusion and exclusion criteria. Randomisation was done through computer software and the trial was double blinded. SPSS version 22 will be used for data analysis.

Enrollment: 82 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-60 yrs, ASA 1 and 2, elective breast cancer surgery

Exclusion criteria

• BMI greater than 35, CKD stage 3 or greater, known drug allergy to study drug, bradycardia, history of PONV, patients on antiepileptics

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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82 participants in 2 patient groups, including a placebo group

Group A, receiving low dose dexmedetomidine infusion

Experimental group

Description:

Group A, receiving low dose dexmedetomidine infusion at 0.6mcg/kg/hour rate

Treatment:

Drug: Dexmedetomidine infusion low dose

Group B, receiving normal saline infusion as placebo

Placebo Comparator group

Description:

normal saline being used as placebo at rate 0.6mch/kg/hour rate

Treatment:

Drug: Group B receiving normal saline