Effect of Dexmedetomidine on Bispectral Index and Propofol Requirements During Different Menstrual Cycle

Fudan University

Status and phase: Completed; Phase 4

Conditions: Abnormal Menstrual Cycle

Treatments: Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02035930

TWang

Details and patient eligibility

About

The study was done to evaluate the effects of the follicular and luteal phases of the menstrual cycle on sedation level at loss of consciousness and bispectral index reach to 50 during propofol anesthesia, in patients with and without preoperative intravenous dexmedetomidine .

Enrollment: 110 patients

Sex: Female

Ages: 24 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• a regular menstrual cycle
• elective gynecologic surgery

Exclusion criteria

• pregnancy
• breastfeeding
• obesity
• known hypersensitivity to drugs used in the study protocol;
• use of psychotropic drugs and steroids within 72 hours before the surgery
• central nervous system injury
• renal impairment
• alcoholism and opioid addiction.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Double Blind

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110 participants in 1 patient group

menstrual cycle,dexmedetomidine

Other group

Treatment:

Drug: dexmedetomidine