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Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Yonsei University logo

Yonsei University

Status

Completed

Conditions

Arthroplasty, Replacement

Treatments

Drug: normal saline
Drug: Dexmedetomidine

Study type

Interventional

Funder types

Other

Identifiers

NCT02648958
4-2015-0794

Details and patient eligibility

About

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

Enrollment

68 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • American Society Anesthesiologists classification I-III

Exclusion criteria

  • use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

68 participants in 2 patient groups, including a placebo group

Control group
Placebo Comparator group
Description:
The control group received saline instead of dexmedetomidine.
Treatment:
Drug: normal saline
Dexmedetomidine group
Experimental group
Description:
The dexmedetomidine group received the dexmedetomidine.
Treatment:
Drug: Dexmedetomidine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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