Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Yonsei University

Status: Completed

Conditions: Arthroplasty, Replacement

Treatments: Drug: normal saline; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02648958

4-2015-0794

Details and patient eligibility

About

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

Enrollment: 68 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society Anesthesiologists classification I-III

Exclusion criteria

• use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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68 participants in 2 patient groups, including a placebo group

Control group

Placebo Comparator group

Description:

The control group received saline instead of dexmedetomidine.

Treatment:

Drug: normal saline

Dexmedetomidine group

Experimental group

Description:

The dexmedetomidine group received the dexmedetomidine.

Treatment:

Drug: Dexmedetomidine