Effect of Dexmedetomidine on Oxygenation and Lung Mechanics

Cairo University (CU)

Status: Not yet enrolling

Conditions: Dexmedetomidine; Drug Use

Treatments: Drug: GROUP B; Drug: GROUP Dexmedetomidine; Drug: GROUP C

Study type: Interventional

Funder types: Other

Identifiers

NCT06355960

2024-853

Details and patient eligibility

About

Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation

Enrollment: 176 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Morbidly obese patients with restrictive lung disease ASA I AND II laparoscopic sleeve gastrectomy

Exclusion criteria

history of heart failure history of cardiac arrhythmias severe liver or kidney impairment. Patients with forced expiratory volume in 1 sec (FEV1)/ FVC < 70%

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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176 participants in 3 patient groups

group A

Active Comparator group

Description:

Dexmedetomidine (Precedex) loadings of 1 μg/kg than continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .

Treatment:

Drug: GROUP Dexmedetomidine

group B

Active Comparator group

Description:

Dexmedetomidine (Precedex) loadings of 0.5 μg/kg then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .

Treatment:

Drug: GROUP B

group C

Active Comparator group

Description:

Dexmedetomidine (Precedex) loadings of 0.25 μg/kg(group C) then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .

Treatment:

Drug: GROUP C