Effect of Dexmedetomidine on Renal Function and Delayed Graft Function After Kidney Transplantation

Yonsei University

Status: Unknown

Conditions: Kidney Transplantation

Treatments: Drug: placebo; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03327389

4-2017-0767

Details and patient eligibility

About

The purpose of this study is to elucidate the effect of dexmedetomidine on renal function and delayed graft function after kidney transplantation

Enrollment: 104 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. adult (20-80 years old)
2. patients undergoing elective kidney transplantation

Exclusion criteria

1. emergency surgery
2. severe sinus bradycardia (<50 beats per min [bpm])
3. second-degree or third-degree heart block
4. decreased heart function (EF <30%)
5. acute myocardial ischemia
6. serious hepatic dysfunction (Child-Pugh class C)
7. patients with known or suspected severe adverse reactions to DEX (or clonidine)
8. treatment with clonidine or dexmedetomidine in the past 30 days

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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104 participants in 2 patient groups, including a placebo group

Dexmedetomidine (Group D)

Experimental group

Description:

Dexmedetomidine infusion during surgery Dexmedetomidine was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure

Treatment:

Drug: Dexmedetomidine

Control (Group C)

Placebo Comparator group

Description:

0.9% NaCl infusion during surgery 0.9% NaCl was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure

Treatment:

Drug: placebo