Effect of Dexmedetomidine on Renal Function and Delayed Graft Function After Kidney Transplantation

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Yonsei University

Status

Unknown

Conditions

Kidney Transplantation

Treatments

Drug: placebo
Drug: Dexmedetomidine

Study type

Interventional

Funder types

Other

Identifiers

NCT03327389
4-2017-0767

Details and patient eligibility

About

The purpose of this study is to elucidate the effect of dexmedetomidine on renal function and delayed graft function after kidney transplantation

Enrollment

104 estimated patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • adult (20-80 years old)
  • patients undergoing elective kidney transplantation

Exclusion criteria

  • emergency surgery
  • severe sinus bradycardia (<50 beats per min [bpm])
  • second-degree or third-degree heart block
  • decreased heart function (EF <30%)
  • acute myocardial ischemia
  • serious hepatic dysfunction (Child-Pugh class C)
  • patients with known or suspected severe adverse reactions to DEX (or clonidine)
  • treatment with clonidine or dexmedetomidine in the past 30 days

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

104 participants in 2 patient groups, including a placebo group

Dexmedetomidine (Group D)
Experimental group
Description:
Dexmedetomidine infusion during surgery Dexmedetomidine was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure
Treatment:
Drug: Dexmedetomidine
Control (Group C)
Placebo Comparator group
Description:
0.9% NaCl infusion during surgery 0.9% NaCl was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure
Treatment:
Drug: placebo

Trial contacts and locations

0

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Central trial contact

Jin Ha Park, MD

Data sourced from clinicaltrials.gov

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