Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery

Yonsei University

Status: Completed

Conditions: Ambulation Difficulty

Treatments: Drug: Dexmedetomidine; Drug: normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01691001

4-2011-0430

Details and patient eligibility

About

Although the aetiology of emergence agitation (EA) derives from multiple factors, it is a frequent side effect of sevoflurane anaesthesia in children. Dexmedetomidine, a potent selective α2-adrenergic agonist, can reduce the doses of hypnotics, opioids, analgesics, and anaesthetics that must be concomitantly administered. This study was conducted to assess the effect of dexmedetomidine infusion on sevoflurane requirements and recovery profiles with EA in children undergoing ambulatory surgery.

Enrollment: 40 patients

Sex: Male

Ages: 1 to 5 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA class I
• obtaining written informed consent from the parents
• aged 1-5 years, and weighing <20 kg who were undergoing ambulatory hernioplasty or orchiopexy

Exclusion criteria

• mental retardation
• developmental delays
• neurological or psychiatric illnesses
• coagulation disorder
• spinal anomalies
• bilateral procedures

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

dexmedetomidine

Experimental group

Treatment:

Drug: Dexmedetomidine

placebo group

Placebo Comparator group

Description:

normal saline

Treatment:

Drug: normal saline