Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation

Seoul St. Mary's Hospital

Status: Completed

Conditions: Lung Cancer

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT04007341

KC16MISI0042

Details and patient eligibility

About

The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.

Enrollment: 40 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective video-assisted thoracoscopic surgery (VATS) lobectomy
• 20 < age < 75
• American Society of Anesthesiologists (ASA) classification I~II

Exclusion criteria

• preoperative inflammation (CRP>10ng/#, WBC>10,000/mm3, body temperature >38#)
• steroid administration within 1 month
• hematologic / autoimmune disease
• congestive heart failure (NYHA class III~IV) or significant arrhythmia
• severe obstructive / restrictive pulmonary disease
• previous history of thoracic surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Saline group

No Intervention group

Description:

Patients in the saline group were infused with an identical volume of normal saline.

Dexmedetomidine group

Experimental group

Description:

Patients in the dexmedetomidine group were infused with a loading dose of dexmedetomidine (1.0 mcg/kg over 10 min) and were thereafter infused at a rate of 0.5 mg/kg/h.

Treatment:

Drug: Dexmedetomidine