Effect of Diet and Physical Activity on Adipokines

Louis Turcanu Emergency Hospital for Children

Status: Completed

Conditions: Obesity, Metabolically Benign

Treatments: Behavioral: MetS+; Other: MetS-

Study type: Observational

Funder types: Other

Identifiers

NCT03435978

13200

Details and patient eligibility

About

The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).

Full description

The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.The prevalence of metabolic syndrome (MetS) in young population continues to rise. Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to determine whether these adipokines are significant markers in defining MetS in pediatric population and to assess the effect of hypocaloric diet and physical activity on serum concentrations of adiponectine, leptin, and high sensitivity CRP (hs-CRP).

The investigators tested the hypothesis that long-term lifestyle changes and moderate weight loss would reduce the plasma concentrations of adipokines involved in inflammation, angiogenesis, and chemotaxis and would increase adiponectin concentrations.

Material and methods:

A prospective study was conducted over a period of 1 year, between January 2016 and December 2016, on 66 cases of obesity in children diagnosed at the Louis Ţurcanu Emergency Hospital for Children Timisoara. The patients diagnosed with MetS were put on diet and physical exercise for 3 months.

Enrollment: 66 patients

Sex: All

Ages: 5 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• obese children (BMI> 95th percentile)

Exclusion criteria

• obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.

Trial design

66 participants in 2 patient groups

MetS+

Description:

Obese group with metabolic syndrome/Data processing from Patient Medical Files

Treatment:

Behavioral: MetS+

MetS-

Description:

Obese group without metabolic syndrome/Data processing from Patient Medical Files

Treatment:

Other: MetS-