Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome

The Washington University

Status: Completed

Conditions: HIV (Human Immunodeficiency Virus); HIV Infections; Metabolic Syndrome

Treatments: Behavioral: Dietary Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT00857298

HW-08-0628

Details and patient eligibility

About

Obese HIV-positive women with Metabolic Syndrome (HIV-MS) and obese HIV-negative women with Metabolic Syndrome will be studied before and after achieving moderate (6%-8%) diet-induced weight loss. The investigators hypothesize that health markers will improve in both groups but that the improvement will be blunted in the women with HIV-MS.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Sedentary
• Obese
• Have either dyslipidemia (HDL < 50 or triglycerides > 150), waist circumference > 88cm, and impaired glucose tolerance or homeostasis model assessment value of > 3
• Subjects with HIV-MS must have been receiving HAART for > 6 months

Exclusion criteria

• Medication changes in the last 3 months
• Diabetes mellitus
• Medical problems that in the opinion of the principal investigator may interfere with patient safety
• Substance abuse

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

HIV-MS

Active Comparator group

Description:

HIV-positive obese women with metabolic syndrome will be studied before and after losing 6-8% of body weight

Treatment:

Behavioral: Dietary Intervention

MS only

Active Comparator group

Description:

HIV-negative obese women with metabolic syndrome will be studied before and after losing 6-8% of body weight

Treatment:

Behavioral: Dietary Intervention