Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity (PerOME)

Laval University

Status: Completed

Conditions: Microbial Colonization; Diet Habit; Activity, Motor

Treatments: Other: 3 maximal aerobic tests

Study type: Interventional

Funder types: Other

Identifiers

NCT04766528

2019-005

Details and patient eligibility

About

Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.

Full description

Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.

Enrollment: 11 patients

Sex: Female

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women
• 20-30 years old
• healthy
• jogging >1h/week and >3h/week of physical activity
• bmi 18.5-25

Exclusion criteria

• postmenopausal, pregnancy or lactation
• pathology or medication
• smoking
• more than 7 alcohol consumption/week
• food allergy, food intolerance or food aversion
• important weight change in the last 6 months
• antibiotics in the last 3 months
• night worker
• pathologies

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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11 participants in 2 patient groups

Mediterannen diet

Experimental group

Description:

The MED diet was abundant in fiber, micronutrients and plant-based proteins. The diet was rich in essential FA like monounsaturated fatty acids (MUFA) and n-3.

Treatment:

Other: 3 maximal aerobic tests

Canadian diet

Experimental group

Description:

The NAM diet had a high content in saturated fatty acids (SFA) and simple sugar and was low in fiber.

Treatment:

Other: 3 maximal aerobic tests