Effect of Diet Orange Soda on Urinary Lithogenicity

VA New York Harbor Healthcare System

Status: Completed

Conditions: Urolithiasis; Kidney Stones; Nephrolithiasis

Treatments: Dietary Supplement: Orange soda

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT01330940

1100

Details and patient eligibility

About

Beverages containing citrate may be useful in increasing urine citrate content and urine pH. Such changes in urine chemistry could help prevent kidney stones. Diet orange soda has more citrate than other similar beverages. The investigators are interested in whether diet soda will improve urine chemistry in the appropriate manner.

Full description

The effect of orange soda compared with water in changing 24 hour urine citrate excretion in mg/day will be determined.

Enrollment: 12 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-65 years old
• able to sign consent
• ability to reliably urinate into a vessel and measure urine volume

Exclusion criteria

• prior history of nephrolithiasis
• a known history of metabolic bone disease
• hyperthyroidism
• hyperparathyroidism or chronic kidney disease
• current use of diuretics
• current use of potassium citrate or other oral alkali supplementation and
• use of calcium supplementation that could not be stopped

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 2 patient groups, including a placebo group

Water drinking

Placebo Comparator group

Description:

32 ounces of water/24 hours

Treatment:

Dietary Supplement: Orange soda

orange soda drinking

Active Comparator group

Description:

32 ounces orange soda

Treatment:

Dietary Supplement: Orange soda