Effect of Dietary Fat on Glycemic Control in Type 1 Diabetes

Joslin Diabetes Center

Status: Completed

Conditions: Type 1 Diabetes

Treatments: Other: High fat meal

Study type: Interventional

Funder types: Other

Identifiers

NCT01292590

2010-P-000140/1 BIDMC;

Details and patient eligibility

About

The purpose of this study is to determine if dietary fat alters insulin requirements in type 1 diabetes.

Full description

This cross-over prospective study will require a two day admission to the clinical research center. Subjects will undergo closed loop glucose control and will received a diet with controlled macronutrient content.

Enrollment: 10 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• type 1 diabetes using insulin pump and CGM

Exclusion criteria

• renal or hepatic failure
• cancer or lymphoma
• malabsorption or malnourishment
• hypercortisolism
• alcoholism or drug abuse
• anemia (hematocrit < 36 in females and <40 in males)
• eating disorder
• dietary restrictions
• Acetaminophen allergy
• Chronic acetaminophen use
• Glucocorticoid therapy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

High fat meal

Experimental group

Treatment:

Other: High fat meal