Effect of Dietary Polyphenols on Insulin Sensitivity

United States Department of Agriculture (USDA)

Status and phase: Completed; Phase 1

Conditions: Insulin Resistance

Treatments: Other: Polyphenols (flavon-3-ol monomers and oligomers)

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT00668928

2005-252

Details and patient eligibility

About

A large and growing segment of the population is prediabetic. Dietary interventions that improve insulin sensitivity may be important in preventing the progression to full-blown diabetes in these individuals. Foods and dietary compounds that increase insulin sensitivity are likely to help maintain a healthier body composition. This pilot study will provide data to evaluate the role of dietary plant polyphenols in improving insulin sensitivity.

Full description

How does the amount consumed of cocoa and tea polyphenols (flavon-3-ol monomers and oligomers) affect insulin sensitivity in insulin resistant individuals?

Enrollment: 20 patients

Sex: All

Ages: 25 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Individuals who are insulin resistant based on routine clinical measurements (Stern et al., 2005).

Exclusion criteria

• BMI < 27 kg/m²
• Age < 25 and > 65 years
• Pregnant women or women who plan on becoming pregnant during the study
• Postpartum women
• Lactating women
• Diabetes mellitus
• Kidney disease
• Liver disease
• Certain cancers
• Smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind