Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease

Lawson Health Research Institute

Status: Completed

Conditions: Chronic Rhinosinusitis; Asthma; Aspirin Exacerbated Respiratory Disease; Aspirin Sensitivity

Treatments: Behavioral: Normal Diet; Behavioral: Low salicylate diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01778465

103330

Details and patient eligibility

About

Aspirin-Exacerbated Respiratory Disease, or AERD, consists of aspirin sensitivity, asthma and nasal polyps. It is currently managed by chronic steroid use, multiple endoscopic sinus surgeries and/or aspirin desensitization. However, these treatments have potential adverse effects.

A theory has been postulated that decreasing the level of dietary salicylates may help in long-term control of disease. A current trial is in the works to evaluate the clinical outcomes of decreased salicylate, but measurements of biochemical markers of disease has not yet been done. The hypothesis is that decreased dietary salicylates will result in a decrease in urinary salicylates and inflammatory markers of disease, cys-leukotrienes, which are typically elevated in this disease.

Enrollment: 7 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients
• Aspirin-exacerbated respiratory disease

Exclusion criteria

• recent use of Prednisone or other systemic steroids (greater than 3 doses in past 3 months)
• Endoscopic sinus surgery or polypectomy within the past 6 months
• Other significant systemic disease, including renal failure, or immunocompromised state.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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7 participants in 2 patient groups

Low salicylate diet, then Normal Diet

Experimental group

Description:

Patients followed a low salicylate diet for one week, then they followed a Normal diet for another week.

Treatment:

Behavioral: Low salicylate diet

Normal diet, then Low Salicylate diet

Experimental group

Description:

Patients followed a Normal diet for one week, then they followed a Low Salicylate diet for another week.

Treatment:

Behavioral: Normal Diet