Effect of Dietary Sodium and Potassium Citrate on Renal Mineral Handling

The University of Chicago

Status: Terminated

Conditions: Kidney Stone

Treatments: Dietary Supplement: Sodium and Potassium Citrate; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03281928

IRB17-0992

Details and patient eligibility

About

This study intends to characterize the affect of sodium and potassium citrate in the diet on renal function.

Enrollment: 30 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 18 - 70, approximately equal numbers of men and women
• studied by endoscopy with complete papillary mapping and grading
• stone formers

Exclusion criteria

• Patients with primary renal diseases or renal impairment (eGFR < 90), or medical conditions such as diabetes, or systemic diseases or medications that alter calcium metabolism
• Patients with known bladder voiding problems

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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30 participants in 4 patient groups, including a placebo group

Low Sodium plus Potassium Citrate

Experimental group

Treatment:

Dietary Supplement: Sodium and Potassium Citrate

Low Sodium plus placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo

High Sodium plus Potassium Citrate

Experimental group

Treatment:

Dietary Supplement: Sodium and Potassium Citrate

High Sodium plus placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo