Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution

Fudan University

Status: Completed

Conditions: Pulmonary Function; Inflammation; Coagulation; Oxidative Stress; Vasoconstriction; Blood Pressure

Treatments: Dietary Supplement: Fish oil supplementation; Dietary Supplement: Sunflower seed oil supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT03255187

FDUEH-3

Details and patient eligibility

About

This study aims to evaluate whether dietary supplementation with fish oil can protect against the cardiopulmonary alterations linked to air pollution

Full description

The investigators conduct a randomized controlled trial among 70 healthy college students in Shanghai, China. These students fulfilling the recruitment criteria will be randomly divided into two parallel groups to receive either fish oil [marine-derived n-3 polyunsaturated fatty acids (PUFA)] or sunflower seed oil. Participants in fish oil group receive 2.5 g/day (two 1.25-g capsules daily) in divided doses. The sunflower seed oil capsules are identical. All interventions started at 7:30 a.m.to avoid issues related to diurnal variation. Health endpoints, including blood pressure, skin color, fractional exhaled nitric oxide and pulmonary function were evaluated and biological samples such as morning urine, fast blood, saliva sample,buccal cells and skin tape stripping will be collected at week 1 before supplemenatation, and week 8, week 10, week 12 as well as week 14 during the supplementation phase.The investigators measure personal real-time exposure to PM2.5 and personal temperature and relative humidity.

Enrollment: 70 patients

Sex: All

Ages: 18 to 27 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Equal to or older than 18 years old.
• No history of smoking and alcohol addiction.
• No chronic diseases or respiratory or allergic diseases,such as hypertension,diabetes,chronic obstructive pulmonary disease,other respiratory/cardiovascular diseases, asthma, rhinitis or other allergic diseases reported by volunteers.
• No allergies to n-3 PUFA or fish.

Exclusion criteria

• Current smokers or ever smokers
• Chronic drug use due on cardiovascular or respiratory diseases
• Participants are taking fish oil,anti-inflammatory drugs, or antioxidant supplements (such as vitamin C or vitamin E)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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70 participants in 2 patient groups, including a placebo group

Fish oil supplementation

Experimental group

Description:

This group receive 2.5 g/day (two 1.25-g capsules daily) of fish oil (marine-derived n-3 PUFA) for 4 consecutive months.

Treatment:

Dietary Supplement: Fish oil supplementation

Sunflower seed oil supplementation

Placebo Comparator group

Description:

This group receive 2.5 g/day (two 1.25-g capsules daily) of placebo (sunflower seed oil) for 4 consecutive months.

Treatment:

Dietary Supplement: Sunflower seed oil supplementation