Effect of Dietary Supplements on the Oral Microbiome

University Center of Dental Medicine Switzerland

Status

Active, not recruiting

Conditions

Nutrition, Healthy

Treatments

Dietary Supplement: Vegetable juice

Study type

Interventional

Funder types

Other

Identifiers

NCT06411977

2019-01896

Details and patient eligibility

About

The oral cavity's microbiome is a diverse community, hosting over 700 bacterial species. Due to its varied niches, the oral cavity constitutes a highly complex environment where different microbes preferentially colonize distinct habitats.

The aim of the study was to investigate the alteration of the oral microbiome during therapy with fixed orthodontic appliances using dietary supplements.

Full description

In the randomized clinical trial, the effect of dietary supplements (vegetable juice) was investigated in patients treated with fixed orthodontic appliances. Saliva, tongue and subgingival samples were taken from each participant at three different time points: TO (before insertion of fixed orthodontic therapy), T1 14 days after daily administration of lettuce juice; T2 up to 6 months after washout. Orthodontic patients without dietary intervention served as controls. In addition, clinical indices were examined. Samples were analyzed by Illumina 16S rRNA sequencing and taxonomically assigned.

Enrollment

22 estimated patients

Sex

All

Ages

12 to 99 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patient age 12 to 99 years
Good general condition, healthy
Inflammation-free marginal periodontium
Metal brackets in the upper and lower jaw

Exclusion criteria

History of allergies
Self reported as being immunocompromised
Self-reported as pregnant or nursing
Self-reported serious medical conditions
Antibiotic or anti-inflammatory medication within 6 months before screening visit
Smoker