Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and Morbidity

Peking University

Status: Completed

Conditions: Postoperative Complications

Treatments: Drug: epidural infusing 2% lidocaine; Drug: remifentanil(Ultiva)

Study type: Interventional

Funder types: Other

Identifiers

NCT01884298

EPIISO-021

Details and patient eligibility

About

In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits of stress block, less depression of breath. however, the epidural technique often causes more drop of blood pressure, especially in dehydrated patients. The investigators designed the trial to see if the benefit weigh out the potential risk of epidural in isolated hypertensive patients.

Enrollment: 180 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults aged 50-70 with isolated systolic hypertension .

Exclusion criteria

• age < 50 yr, ASA grade IV, severe cardiac or pulmonary insufficiency (FEV1 < 1 litre) , malignant hypertension, psychiatric illness (intake of psychiatric medication other than selective serotonin re-uptake inhibitors), diastolic blood pressure more than 110 mmHg. emergency surgery, coagulopathy, significant renal and hepatic dysfunction (creatinine > 50% or liver enzymes > 50% upper limit of normal values)

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Triple Blind

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180 participants in 1 patient group

patients with isolated systolic hypertension

Experimental group

Description:

patients combined with isolated systolic hypertension undergoing abdominal surgery

Treatment:

Drug: remifentanil(Ultiva)

Drug: epidural infusing 2% lidocaine