Effect of Different Biomimetic Materials on White Spot Lesions in Enamel

Benha University

Status: Completed

Conditions: White Spot Lesion

Treatments: Other: Time of assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT05001035

OPDEN-107-1-G (Other Identifier)

OP-P-018-001

Details and patient eligibility

About

This study will be conducted to evaluate: 1- The remineralizing effect of different biomimetic materials (Zinc carbonate hydroxyapatite nanoparticles, Poly-amido amine (PAMAM) and bioactive glass nanoparticles) on white spot lesions in enamel. 2- The clinical efficacy of these agents on disappearance of these white spots.

Enrollment: 21 patients

Sex: All

Ages: 15 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Total of 21 patients enrolled in this study will be selected having at least 4 teeth (one on each quadrant) which will be extracted for orthodontic treatment.
• These patients will be selected according to age groups between 15-25 years old
• good oral hygiene
• free of destroying habits for dental tissues

Exclusion criteria

• Bruxism
• soft drinks consumption
• acid regurgitation, etc.).
• Selected teeth having any cracks, malformations, dysplasia or caries.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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21 participants in 4 patient groups

Zinc carbonated hydroxy apatite

Experimental group

Description:

Toothpaste to be added on white spot lesions in dental enamel

Treatment:

Other: Time of assessment

Bioactive glass

Experimental group

Description:

Toothpaste to be added on white spot lesions in dental enamel

Treatment:

Other: Time of assessment

Poly amido amine

Experimental group

Description:

Resinous material to be painted on white spot lesions in dental enamel

Treatment:

Other: Time of assessment

Control

No Intervention group

Description:

No material to be added