Effect of Different Concentrations of Lidocaine in Relieving Pain in Wide Awake Hand Surgery Using Tumescence

King Edward Medical University

Status and phase: Completed; Phase 1

Conditions: Lidocaine

Treatments: Drug: lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT04692896

27/RC/KEMU

Details and patient eligibility

About

Lidocaine has been used along with adrenaline in tumescent anesthesia for a variety of procedures. This has been quite popular especially in wide awake surgery of the hand with no tourniquet. However, the appropriate lidocaine concentration is yet to be established. This randomized control trial will study the minimum effective lidocaine concentration in hand surgery using the tumescent technique.

Enrollment: 90 patients

Sex: All

Ages: 16 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients aged 16 to 60 years of either gender
2. Patients with post burn/post traumatic contractures involving fingers & palm
3. Patients with nerve injury or flexor/extensor tendons injury distal to mid forearm.

Exclusion criteria

1. Patients with history of ischemic heart disease, chronic liver disease (ALT/AST 40 IU/L), renal disease (creatinine 13mg/dl), bleeding disorder, peripheral arterial disease & peripheral neuro3pathy .
2. Surgical site infection .
3. History of allergic hypersensitivity to epinephrine or lidocaine.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

90 participants in 3 patient groups

0.1% lidocaine

Experimental group

Treatment:

Drug: lidocaine

0.2% lidocaine

Experimental group

Treatment:

Drug: lidocaine

0.3% lidocaine

Experimental group

Treatment:

Drug: lidocaine