Effect of Different Concentrations of Xylitol and Erythritol on Gut Peptide Release and Gastric Emptying in Humans

University Hospital Basel

Status: Completed

Conditions: Physiological Satiation Mechanisms

Treatments: Dietary Supplement: Erythritol 25g; Dietary Supplement: Xylitol 7g; Dietary Supplement: Xylitol 17g; Dietary Supplement: Erythritol 50g; Dietary Supplement: Xylitol 35g; Dietary Supplement: Erythritol 10g

Study type: Interventional

Funder types: Other

Identifiers

NCT03039478

PolyDose

Details and patient eligibility

About

Xylitol and erythritol have become increasingly popular as sugar substitutes in the food industry. Both substances are freely available. While glucose ingestion stimulates satiation hormone secretion in the gut and slows down gastric emptying, artificial sweeteners such as aspartame, sucralose and acesulfame-K have no such effect. However, acute intake of 50g xylitol or 75g erythritol in 300mL tap water leads to a marked increase in the satiation hormones and induces a significant retardation in gastric emptying. The concentrations used to Show this effect were rather high (50g xylitol and 75g erythritol) and led to bloating and diarrhea in 60-70% of all subjects two hours after administration. The aim of the present study is to find an effective concentration of xylitol and erythritol still stimulating satiation hormone release without any gastrointestinal adverse events.

Enrollment: 24 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy normal weight subjects with a body-mass index of 19.0-24.9
• Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan)
• Age 18-40 years
• Stable body weight for at least three months
• Informed Consent as documented by signature

Exclusion criteria

• Pre-existing consumption of xylitol or erythritol on a regular basis (usage of xylitol or erythritol as sugar replacement; xylitol or erythritol containing toothpaste is allowed)
• Regular intake of medications (except for oral contraceptives)
• Evidence of relevant cardiovascular, pulmonary, renal, hepatic, pancreatic, gastrointestinal, metabolic, endocrinological, neurological, psychiatric or other diseases at screening
• Clinically relevant abnormalities in haematological laboratory parameters
• Food allergies, food intolerance
• Pregnancy
• Participation in another study with investigational drug within the 30 days preceding and during the present study.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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24 participants in 6 patient groups

Xylitol 7g in 300mL tap water

Active Comparator group

Description:

12 volunteers receive 7g xylitol in 300mL tap water via a nasogastric tube

Treatment:

Dietary Supplement: Xylitol 7g

Xylitol 17g in 300mL tap water

Active Comparator group

Description:

12 volunteers receive 17g xylitol in 300mL tap water via a nasogastric tube

Treatment:

Dietary Supplement: Xylitol 17g

Xylitol 35g in 300mL tap water

Active Comparator group

Description:

12 volunteers receive 35g xylitol in 300mL tap water via a nasogastric tube

Treatment:

Dietary Supplement: Xylitol 35g

Erythritol 10g in 300mL tap water

Active Comparator group

Description:

12 volunteers receive 10g erythritol in 300mL tap water via a nasogastric tube

Treatment:

Dietary Supplement: Erythritol 10g

Erythritol 25g in 300mL tap water

Active Comparator group

Description:

12 volunteers receive 25g erythritol in 300mL tap water via a nasogastric tube

Treatment:

Dietary Supplement: Erythritol 25g

Erythritol 50g in 300mL tap water

Active Comparator group

Description:

12 volunteers receive 50g erythritol in 300mL tap water via a nasogastric tube

Treatment:

Dietary Supplement: Erythritol 50g