Effect of Different Liquids Intake in Vasovagal Reaction After Whole Blood Donation

Guangzhou Blood Center

Status: Completed

Conditions: Blood Donation

Treatments: Dietary Supplement: water with white granulated sugar; Drug: Oral Rehydration Salts power (iii); Dietary Supplement: water

Study type: Interventional

Funder types: Other

Identifiers

NCT05319951

Different liquids intake

Details and patient eligibility

About

we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation

Full description

Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar & salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction.

However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.

Enrollment: 6,250 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:All blood donors donated whole blood in Guangzhou Blood Center during study.

Exclusion Criteria:Blood donors who were deferral by blood screening result and other situations.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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6,250 participants in 3 patient groups, including a placebo group

Oral Rehydration Salts Power (iii)

Experimental group

Description:

Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Treatment:

Drug: Oral Rehydration Salts power (iii)

water with white granulated sugar

Experimental group

Description:

Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.

Treatment:

Dietary Supplement: water with white granulated sugar

recommended water intake

Placebo Comparator group

Description:

Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Treatment:

Dietary Supplement: water