Effect of Different Non-surgical Treatment Approaches of Peri-implantitis

Yeditepe University

Status: Completed

Conditions: Peri-implant Inflammation; Peri-Implantitis and Peri-implant Mucositis; Non-surgical Treatment

Treatments: Procedure: Submarginal mechanical instrumentation and chlorhexidine irrigation; Procedure: Submarginal mechanical instrumentation; Procedure: Submarginal mechanical instrumentation and air abrasion; Procedure: Air abrasion monotherapy; Procedure: Submarginal mechanical instrumentation and ozone application

Study type: Interventional

Funder types: Other

Identifiers

NCT06730568

PI-RCT

Details and patient eligibility

About

Peri-implantitis is a biofilm-associated pathological condition characterized by inflammation within the peri-implant mucosa, which leads to the progressive loss of the surrounding supporting bone tissue. The primary goal of managing peri-implantitis is to control the peri-implant biofilm and resolve inflammation. Nonsurgical treatment of peri-implantitis by submarginal mechanical instrumentation alone typically provides clinical improvements, particularly in non-advanced cases. However, to ensure surface decontamination and enhance treatment outcomes, alternative or adjunctive methods, such as systemic/local antibiotics, antiseptics, lasers, and air-abrasion systems, have been proposed.

Therefore, the null hypothesis (H0) of the present study is that no statistically significant difference would be detected in clinical inflammation signs among patients diagnosed with early-stage peri-implantitis after undergoing one of the following treatments: nonsurgical mechanical instrumentation alone, mechanical instrumentation plus chlorhexidine (CHX), mechanical instrumentation plus gaseous ozone, mechanical instrumentation plus glycine air polishing, or glycine air polishing alone.

Enrollment: 26 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• the presence of at least one titanium implant with clinical and radiographic signs of initial to moderate peri-implantitis
• single-unit or partial restorations without overhangings
• absence of occlusal overload
• the presence of at least 2 mm of keratinized attached peri-implant mucosa
• periodontally healthy participants with a good level of oral hygiene

Exclusion criteria

• the presence of implant mobility
• systemic diseases (i.e. diabetes (HbA1c <7), osteoporosis, bisphosphonate medication) which could affect the outcome of treatment
• smoking
• placement, and prosthetic loading of implants within the past year

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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26 participants in 5 patient groups

Mechanical Instrumentation (M)

Active Comparator group

Description:

The participants in the mechanical instrumentation (M) group were treated with conventional submarginal instrumentation using titanium curettes.

Treatment:

Procedure: Submarginal mechanical instrumentation

Mechanical Instrumentation with Chlorhexidine (MC)

Experimental group

Description:

Participants in the mechanical instrumentation with chlorhexidine (MC) group were treated with conventional submarginal instrumentation using titanium curettes followed by adjunctive chlorhexidine irrigation.

Treatment:

Procedure: Submarginal mechanical instrumentation and chlorhexidine irrigation

Mechanical Instrumentation with Ozone (MO)

Experimental group

Description:

Participants in the mechanical instrumentation with chlorhexidine (MC) group were treated with conventional submarginal instrumentation using titanium curettes followed by gaseous ozone

Treatment:

Procedure: Submarginal mechanical instrumentation and ozone application

Mechanical Instrumentation with Air Abrasion (MA)

Experimental group

Description:

The participants in the mechanical instrumentation with glycine powder air abrasion (MA) group were treated with conventional submarginal instrumentation using titanium curettes and followed by adjunctive glycine air-abrasion.

Treatment:

Procedure: Submarginal mechanical instrumentation and air abrasion

Air Abrasion Monotherapy (A)

Experimental group

Description:

The participants in the air abrasion monotherapy (A) group were treated exclusively with glycine powder-based air abrasion.

Treatment:

Procedure: Air abrasion monotherapy