Effect of Different Protein Diets on Glucose and Insulin Metabolism and Substrate Partitioning

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Insulin; Glucose Metabolism

Treatments: Dietary Supplement: High GI; Dietary Supplement: vegetable protein; Dietary Supplement: Control; Dietary Supplement: High dairy protein

Study type: Interventional

Funder types: Other

Identifiers

NCT01034241

MEC 08-3-072

Details and patient eligibility

About

The purpose of this study is to determine whether different protein diets affects glucose and insulin metabolism and substrate partitioning.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI: 18.5-25 kg/m2 (lean)
• Gender: Male
• Age: <35 years
• Caucasian

Exclusion criteria

• Elevated fasting blood glucose level
• Lactose intolerant
• Diabetes Mellitus
• Hypertension (systolic/diastolic blood pressure)
• Hypotension (systolic/diastolic blood pressure)
• Cardiovascular diseases
• Asthma and other obstructive pulmonary diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

12 participants in 4 patient groups

Control

Experimental group

Description:

Diet consists of 15% dairy protein and low Glycemic Index (GI < 40), 55 En% carbohydrates and 30 En% fat

Treatment:

Dietary Supplement: Control

High dairy protein

Experimental group

Description:

Diet consists of 25% dairy protein and low GI (GI < 40), 45 En% carbohydrates and 30 En% fat

Treatment:

Dietary Supplement: High dairy protein

vegetable protein

Experimental group

Description:

Diet consists of 15 En% vegetable protein and low GI (GI < 40), 55 En% carbohydrates and 30 En% fat

Treatment:

Dietary Supplement: vegetable protein

High GI

Experimental group

Description:

Diet consists of 15 En% dairy protein and high GI(GI > 60, 55 En% carbohydrates and 30 En% fat

Treatment:

Dietary Supplement: High GI