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Effect of Different Types of Aerobic Training on Peak VO2 and Ejection Fraction for Diastolic Heart Failure Patients; a Comparative Randomized Control Trial

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Beni-Suef University

Status

Completed

Conditions

Effect of Different Types of Aerobic Training on Diastolic Heart Failure Patients

Treatments

Other: aerobic exercise for upper limb
Other: aerobic exercise for lower limb

Study type

Interventional

Funder types

Other

Identifiers

NCT05637125
BeniSuefU2

Details and patient eligibility

About

Background: Heart failure is described by a lack of confirmed efficient therapies and exercise intolerance. Physical activity is related to a lower risk of adverse cardiovascular consequences, involving heart failure. The purpose of the study: determine the effect of different types of aerobic training on peak VO2 and ejection fraction in diastolic heart failure patients. Subject and methods: Forty eligible male patients with diastolic heart failure, aged between 50 - 60 years old, participated in this study. They were selected from an outpatient clinic of general Zagazig hospital and were assigned into 2 equal groups in numbers. The first group (A) received aerobic exercise for the upper limb in form of arm ergometer exercises, while the second group (B) received aerobic exercise for the lower limb in form of cycling. Training duration for both groups was 3 sessions/week for 12 weeks. Peak VO2, and ejection fraction of both groups were measured and compared pre and post-treatment. Results: There was no significant difference in the ejection fraction between groups post-treatment. There was a significant increase in the peak VO2 of group B compared with that of group A post-treatment. Conclusion: there is no effect of different types of aerobic training on ejection fraction and peak VO2 for diastolic heart failure patients, but lower limb exercise is more effective than upper limb exercise in improvement of peak VO2 for diastolic heart failure patients.

Full description

Ejection fraction and peak VO2 of both groups were measured pre exercise program and after 12 weeks at the end of the study exercise program.

  • Vivid S5 cardiovascular ultrasound system (BT308), made in china, was used to measure ejection fraction.
  • Oxycon pro (ER900, Germany) cardiopulmonary exercise test unit was used to measure Peak Vo2

Treatment procedure:

Group A received aerobic exercise for upper limb in the form of arm ergometer 3 session/week for 12 weeks. Patient started with warming up for 5 minutes in form of stretching. Patients used arm ergometer without resistance for upper limb aerobic exercise for 20 minutes and instructed to take rest if they feel tired or fatigue. The intensity was according to rate of perceive exertion, after 20 minutes, patients were asked to cool down for 5 minutes in the form of stretching at the end of an exercise session.

Group B received aerobic exercise for lower limb in the form of cycling 3session/week for 12 weeks. Patient started with warming up for 5 minutes. Patients used bicycle for lower limb aerobic exercise for 20 minutes and instructed to take rest if they feel tired or fatigue. The intensity was according to rate of perceive exertion. After 20 minutes, patients were asked to cool down for 5 minutes in the form of stretching at the end of an exercise session.

Enrollment

40 patients

Sex

Male

Ages

50 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • male gender
  • under complete medical supervision
  • left ventricular end diastolic dimension >5.5cm
  • ejection fraction <50%.

Exclusion criteria

  • Orthopedic problems
  • Mental disorders
  • Metabolic disorders (D.M)
  • Current treatment for cancer or active infection.

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

40 participants in 2 patient groups

Group A
Active Comparator group
Description:
Group A received aerobic exercise for upper limb in the form of arm ergometer 3 session/week for 12 weeks.
Treatment:
Other: aerobic exercise for upper limb
Group B
Active Comparator group
Description:
received aerobic exercise for lower limb in the form of cycling 3session/week for 12 weeks.
Treatment:
Other: aerobic exercise for lower limb

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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