Effect of Different Ultrasound Doses on Median Nerve Conduction Parameters

Cairo University (CU)

Status: Enrolling

Conditions: Entrapment Neuropathies

Treatments: Device: Pulsed Ultrasound Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05233488

REC-43/02/008

Details and patient eligibility

About

The current study investigates the effect of different doses of pulses ultrasound therapy on different nerve conduction parameters of the median nerve in healthy volunteering subjects.

Full description

In the current study, we apply pulsed ultrasound therapy on median nerves of healthy volunteer subjects, at 1 W/cm2 10% duty cycle, 3 W/cm2 10% duty cycle, 1 W/cm2 50% duty cycle, and 3 w/cm2 50% duty cycle. Parameters of median nerve conduction study, Latency, amplitude, area, duration and forearm NCV are recorded before and after application of ultrasound therapy.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 24 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. 120 hands of 60 subjects of both genders with age range 18: 24 years.
2. Subjects assigned will be apparently healthy subjects with no neurological or neuromuscular history affecting the upper limb.

Exclusion criteria

1. Peripheral polyneuropathy.
2. Diabetes mellitus.
3. Previous surgeries or median and/or ulnar nerve release.
4. Cervical radiculopathy.
5. Median or ulnar entrapment neuropathies.
6. Previous or current pregnancies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 4 patient groups

Low US dose

Experimental group

Description:

Pulsed US, 1 W/cm2, 10% duty cycle.

Treatment:

Device: Pulsed Ultrasound Therapy

Intermediate US dose

Experimental group

Description:

Pulsed US, 1 W/cm2, 50% duty cycle.

Treatment:

Device: Pulsed Ultrasound Therapy

High US dose

Experimental group

Description:

Pulsed US, 3 W/cm2, 10% duty cycle.

Treatment:

Device: Pulsed Ultrasound Therapy

Higher US dose

Experimental group

Description:

Pulsed US, 3 W/cm2, 50% duty cycle.

Treatment:

Device: Pulsed Ultrasound Therapy