Effect of Different Ventilation Modes on POCD in Elderly Patients with Abdominal Wall Hernia

Inner Mongolia University of Science and Technology

Status: Completed

Conditions: Optic Nerve Sheath Edema; Postoperative Cognitive Impairment

Treatments: Device: VC Ventilation Modes; Device: PC Ventilation Modes; Device: PRVC Ventilation Modes

Study type: Interventional

Funder types: Other

Identifiers

NCT06764745

MER-076

Details and patient eligibility

About

The purpose of this clinical trial is to understand the effect of different ventilation patterns during surgery on postoperative cognitive impairment in elderly patients with abdominal wall hernias. It will also explore how to reduce the incidence of postoperative cognitive impairment. The main questions it aims to answer are:

• Does the mode of ventilation affect the incidence of postoperative cognitive impairment in elderly patients?
• Does optic nerve sheath edema affect the incidence of postoperative cognitive impairment in elderly patients? Researchers will monitor patients with different ventilation patterns intraoperatively and investigate postoperatively to see if the ventilation pattern affects postoperative cognitive impairment.

Participants will:

• Randomly assigned to groups with different ventilation patterns
• Record various values during surgery by the researchers
• Presence of cognitive impairment assessed by cognitive scales after surgery

Enrollment: 471 patients

Sex: All

Ages: 65 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: 65-90 years
• patients with abdominal wall hernias
• American Society of Anesthesiologists general status (ASA-PS) classes II and III.

Exclusion criteria

• Emergency (rather than elective) surgery or other types of surgery required
• More than one surgery required during hospitalization
• Preoperative demonstrated inability to communicate (due to coma, severe dementia, Parkinson's disease, severe hearing or visual impairment, or speech impairment).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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471 participants in 3 patient groups

PC Ventilation patterns Group

Experimental group

Description:

Ventilation Modes Following induction, Group I patients received mechanical ventilation using the PC mode.

Treatment:

Device: PC Ventilation Modes

VC Ventilation patterns Group

Experimental group

Description:

Ventilation Modes Following induction, Group II patients received mechanical ventilation using the VC mode.

Treatment:

Device: VC Ventilation Modes

PRVC Ventilation patterns Group

Experimental group

Description:

Ventilation Modes Following induction, Group III patients received mechanical ventilation using the PRVC mode.

Treatment:

Device: PRVC Ventilation Modes