Effect of Dihydrocapsiate on Energy Expenditure in Women

E

Ellen Evans

Status

Completed

Conditions

Obesity

Treatments

Dietary Supplement: Dihydrocapsiate

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT01773356
WASABI

Details and patient eligibility

About

The objective of this study is to test the effect of dihydrocapsiate on energy expenditure in women.

Full description

Capsaicin, a substance found in chili pepper, is known to stimulate thermogenesis. Dihydrocapsiate, a capsinoid, found in the non-pungent CH-19 sweet pepper has similar thermogenic effects without the gastrointestinal side effects. The objective of this project is to test the effect of 12 weeks of daily consumption of 9 mg dihydrocapsiate on resting energy expenditure relative to baseline when compared to a control group consuming products without DCT.

Enrollment

126 patients

Sex

Female

Ages

25 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • BMI: 18.5-34.5 kg/m2
  • Good general health
  • Low to mild physical activity
  • Willing to maintain habitual diet and physical activity patterns throughout the study period
  • Premenopausal and cycling regularly or using oral contraceptives
  • Willing to attend study visits only during the follicular phase or bleed phase of their menstrual cycle
  • Understands study procedures and signs forms providing informed consent to participate in the study
  • Have spoken and written English literacy

Exclusion criteria

  • Diabetes mellitus or any conditions that might affect energy metabolism
  • Weight change ±2 kg over previous three months
  • Known sensitivity or allergy to ingredients of the study products
  • Non-breakfast eater
  • Recent use of antibiotics
  • History of smoking during the six months prior to study
  • Recent signs or symptoms of infection, including cold or flu-like symptoms
  • Concurrent or recent intervention study participation
  • Instability in breathing patterns or energy expenditure measures
  • History of drug or alcohol abuse
  • Lipid-lowering, anti-hypertensive or anti-inflammatory steroid medication use
  • Weight loss medication
  • Pregnant or lactating
  • Unwilling to be randomized to any experimental group and unable to meet all requirements of the study

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

126 participants in 2 patient groups, including a placebo group

Placebo 0 mg/d
Placebo Comparator group
Description:
0 mg/d of Dihydrocapsiate will be consumed in ready to ear cereal, cereal bars or crackers
Treatment:
Dietary Supplement: Dihydrocapsiate
Dihydrocapsiate 9 mg/d
Active Comparator group
Description:
9 mg/d of Dihydrocapsiate will be consumed in ready to ear cereal, cereal bars or crackers
Treatment:
Dietary Supplement: Dihydrocapsiate

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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