Effect of Dill in Thyroiditis and Nodular Goiter Patients

Bezmialem Vakif University

Status: Completed

Conditions: Thyroid Nodule

Treatments: Dietary Supplement: Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.

Study type: Interventional

Funder types: Other

Identifiers

NCT04482907

12.2014/21

Details and patient eligibility

About

The aim of the study was to investigate the functional and morphological effects of Anethum graveolens L. in patients with thyroiditis and nodular goiter by evaluating hormone levels, anti-Inflammatory markers and comparing thyroid nodule sizes measured by ultrasonography for 90 days.

The effect of Anethum graveolens L. was evaluated in euthyroid goiter patients diagnosed with benign thyroid nodule via fine needle aspiration biopsy. Aerial parts of Anethum graveolens L. were dried and grinded to yield a fine powder. Size 1 hydroxypropyl methylcellulose capsules were filled with 300 mg powder. Placebo was prepared in the same manner using maltodextrin. Patients were suggested to take 3 pills a day. Blood samples were collected at the initial and the final day for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (Anti-Tg) and C-reactive protein (CRP) analysis. Nodule sizes were also measured at the beginning and at the end of the trial with ultrasonography to identify the changes and effectiveness of dill dosage forms.

After 90 days in the study, the status of TSH, fT3, fT4, anti-TPO and CRP levels were examined in the group with and without Anethum graveolens L..

Again, after the study, the size of thyroid nodules was evaluated in the group who received and did not receive Anethum graveolens L. by ultrasonography.

Enrollment: 68 patients

Sex: All

Ages: 18 to 76 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• To have multi-nodular goiter,
• To be a benign result in fine needle aspiration biopsy,
• Euthyroid must be sick,
• Must be sick over the age of 18,
• To accept the research.

Exclusion criteria

• Thyroid function tests non-euthyroid individuals,
• To have a malignant result in thyroid biopsy,
• Not giving approval,
• To be renal failure,
• Benign pregnant,
• Taking blood thinning drugs

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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68 participants in 2 patient groups, including a placebo group

Group receiving dill

Active Comparator group

Description:

They took 3 meals a day, 3x300 mg dry dill powder by mouth. They bought dry dill powder for 90 days.

Treatment:

Dietary Supplement: Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.

Group receiving placebo

Placebo Comparator group

Description:

They took 3 meals a day and 3 cellulose placebo capsules by mouth. They took placebo capsules for 90 days.

Treatment:

Dietary Supplement: Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.