Effect of Domperidone on Completion Rate of Vedio Capsule Endoscopy

Fudan University

Status: Completed

Conditions: Pediatric Disorder; Capsule Endoscopy

Treatments: Dietary Supplement: water; Drug: Domperidone

Study type: Interventional

Funder types: Other

Identifiers

NCT03662113

DomperidoneVCE

Details and patient eligibility

About

Video capsule endoscopy (VCE) has become an established technique to investigate the presence of small bowel pathology. But the limited battery life of capsules can lead to incomplete small bowel visualization. There is a rationale to use prokinetic agents prior to VCE reduce the chances of an incomplete small bowel examination via decrease gastric transit time (GTT). Investigators are aimed to prospectively compare the completion rate of VCE in pediatric patients receiving prokinetic with those receiving no prokinetic.

Full description

Eligible children were randomly divided into two groups: domperidone prior to VCE and water prior to VCE. The primary outcome measure was the completion rate. Secondary outcome measures included the GTT and SBTT.

Enrollment: 200 patients

Sex: All

Ages: 3 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Indications of capsule endoscopy;
• Informed consent form obtained.

Exclusion criteria

• Contraindication of capsule endoscopy;
• Domperidone allergy;
• Unwilling to participate.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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200 participants in 2 patient groups

Experimental: Domperidone

Experimental group

Description:

5ml domperidone prior to VCE

Treatment:

Drug: Domperidone

Control: water

Other group

Description:

5ml warm water prior to VCE

Treatment:

Dietary Supplement: water